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Pablo Villanueva Perez

Senior lecturer

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Assessing lesion malignancy by scanning small-angle x-ray scattering of breast tissue with microcalcifications

Author

  • C. Arboleda
  • V. Lutz-Bueno
  • Z. Wang
  • P. Villanueva-Perez
  • M. Guizar-Sicairos
  • M. Liebi
  • Zsuzsanna Varga
  • M. Stampanoni

Summary, in English

Scanning small-angle x-ray scattering (SAXS) measurements were performed on 36 formalin-fixed reast tissue biopsies obtained from two patients. All samples contained microcalcifications of ype II, i.e. ormed by hydroxyapatite. We demonstrate the feasibility of classifying breast lesions by canning SAXS of issues containing microcalcifications with a resolution of 35 μm x30 μm. We eport a characteristic Bragg eak found around q = 1.725 nm-1 that occurs primarily for malignant esions. Such a clear SAXS fingerprint s potentially linked to structural changes of breast tissue nd corresponds to dimensions of about 3.7 nm. This aterial property could be used as an early ndicator of malignancy development, as it is readily assessed by AXS. If this fingerprint is combined ith other known SAXS features, which also indicate the level of alignancy, such as lipid spacing and collagen periodicity, it could complement traditional pathology-based analyses. To confirm the SAXS-based classification, a histopathological workup and a gold standard histopathological diagnosis were conducted to determine the malignancy level of the lesions. Our aim is to report this SAXS fingerprint, which is clearly related to malignant breast lesions. However, any further conclusion based on our dataset is limited by the low number of patients and samples. Running a broad study to increase the number of samples and patients is of great importance and relevance for the breast-imaging community.

Department/s

  • MAX IV Laboratory

Publishing year

2019-08-06

Language

English

Publication/Series

Physics in Medicine and Biology

Volume

64

Issue

15

Document type

Journal article

Publisher

IOP Publishing

Topic

  • Radiology and Medical Imaging

Keywords

  • breast cancer
  • breast lesion diagnosis
  • breast micro calcifications
  • small-angle x-ray scattering

Status

Published

ISBN/ISSN/Other

  • ISSN: 0031-9155